amofit S : Wearable for Sleep and Healthy Aging

Shortcut to Longevity
and Health

Aging can be thought of as a decrease in the body's ability to maintain homeostasis, our body's ability to "self-tune" or self-stabilize in response to stressors. Our challenge is to restore homeostasis, a unique and innate human ability, through our innovative bioelectronic technology to lead healthier lives and delay aging by stimulating the cardiac branch of the vagus nerve and correcting the imbalance of the autonomic nervous system.

Everything is in the
Vagus Nerve 

Chronic stress, anxiety, and lack of sleep negatively impact our immune system and its balance and increase the risk of developing or worsening diseases.

The vagus nerve is the longest in the body. It is the main component of the parasympathetic nervous system of the autonomic nervous system and is the conductor of all immune defense mechanisms. If the vagal tone is activated, the parasympathetic nervous system functions properly, and the risk of high blood pressure, heart disease, and stroke are reduced. It is also good for the intestines by improving digestive metabolism and decreasing migraines. Not only will this allow you to age healthier, but it also lowers an individual's risk of death and the need for medication or hospital visits.
 

HRV (Heart rate variability) functions as a biomarker in health and disease. It is also the best biomarker to track our longevity.

The chart above shows our clinical trial results on HRV, conducted at KRISS. In this double-blind, placebo-controlled clinical trial, we obtained results that showed the activities of the parasympathetic nerves of the autonomic nervous system were increased by over 275% by stimulating the cardiac branch of the vagus nerve.

We have yet to find other neuromodulation technology or medical technology that can change and regulate the parasympathetic nervous system, which controls the body's unconscious behavior and functions, so dramatically within just one day.

Wear 'amofit S' for 30 minutes per day. Restore your body and mind to their original, natural state in just a few days.

amofit S is a unique bioelectronic wearable device that improves the overall human body by transmitting mild electromagnetic signals to the nervous system through the vagus nerve in the chest area in the form of electric currents. It improves sleep, stress, and anxiety by restoring the balance of the autonomic nervous system. It also enhances memory and creativity by promoting the generation of alpha brain waves and restores the internal balance through homeostatic autoregulation mechanism.

Studies have shown that vagus nerve stimulation treatment can delay significant effects related to aging. This may help protect people from chronic diseases that are more likely to occur as people get older.
 

'amofit S', with AMO Lab's proprietary neuromodulation technology, cVES (cervicothoracic vagus electromagnetic stimulation), targets the vagus nerve in the human's autonomic nervous system. With a mild intensity similar to the innate magnetic field generated by the human body itself, the electromagnetic signal passes through the skin, muscles, and bones without any interference. It then is transmitted to the vagus nerve in the chest area. This signal regulates the vagal tone and activates the parasympathetic nervous system.

'amofit S' provides two healing modes. After powering on the device, you can switch from CALM mode to FOCUS mode by pressing the touch area. CALM mode can increase the vagal tone and activate the parasympathetic nervous system to improve sleep, stress, and anxiety and correct the body's internal balance, as well as help with chronic diseases related to problems in the vagus nerve and the autonomic nervous system. FOCUS mode can enhance memory and creativity by increasing alpha brain waves.

Attach the device to your collar using the clip on the back of the device or wear it like a necklace around your neck. This simple, sophisticated device will improve your dignity.

Effectiveness has been proven through rigorously-controlled clinical trials.

In clinical trials on heart rate variability (HRV), melatonin, and brain wave analysis, the effects of improving sleep and stress and enhancing concentration and memory were proven.

The fundamental effect of amofit S that activates vagal tone and parasympathetic nervous system restores the body's internal balance and can potentially help with symptoms of the chronic neurological diseases such as autonomic dysfunction.

Non-Contact Neurotechnology

Unlike existing neurostimulation devices, 'amofit S' does not require strong stimulation and does not need to be attached to the skin. The electromagnetic signal generated by 'amofit S' is effective within a 9-inch radius from the heart and can be worn over clothing without any inconvenience.

Rapid Effects

According to our clinical studies and the reviews from our users, more than 60% of users experience the benefits after the first 1-3 days of use. Most importantly, clinical reports demonstrate that people with severe symptoms experience higher effects. Additionally, most users, particularly those with severe sleep problems, report significant improvement on the first day of use.

Long-Lasting Effects

In our first clinical trial, we achieved a remarkable result that the effect lasted more than 72 hours after using the device for just 2 hours. This is an innovative scientific result, which is difficult to achieve with existing neuromodulation technologies.

Safety

The mild electromagnetic signal generated by 'amofit S' operates at a very low level compared to the intensity of the magnetic field generated by the human body and equivalent to 1/10 of the Earth's electromagnetic field. Natural neurostimulation based on the principle of the human body entrainment does not have any side effects and guarantees higher safety.
 

Wearing the Device

'amofit S' is applied with non-contact neurostimulation technology with an effective range of 9 inches and can be worn by using a necklace string or by clipping the product to your collar.

This device is simple and convenient to use anytime, anywhere in your daily life. Many aspects of your life will be improved from the day after the first use.

It would be the perfect gift for your beloved family.

Crowdfunding Campaign (wadiz.co.kr)

We successfully launched our first-generation product 'AMO+' in 2019 on 'Wadiz', a crowdfunding platform in South Korea. Ultimately, we shipped the products to all 2,249 backers. The product’s review score rated by our backers was 4.5/5.0.

For the following 2 years after the launch, we communicated with our Korean backers and many of our users to improve product functions and treatment protocols. We have just launched our new product, 'amofit S', on this Indiegogo crowdfunding campaign.

Clinical Trials & Academic Papers

We demonstrated the effectiveness in all three clinical trials conducted at KRISS, a Korean government institute, and Kyunghee University Hospital. We also published two academic papers in the international journal Springer Nature. 

Exclusive Patents

We have a broad portfolio of intellectual property rights, with 7 patents registered worldwide, including PCT, EU, USA, South Korea, Japan, China, and Taiwan, on vagus nerve stimulation method and technology.

International Certification

'amofit S' is a safe product that has obtained various international certifications.

Product Function

Tech Specs

The results from 10 years of research were proven through 3 clinical trials.

In clinical trials conducted at the KRISS (Korea Research Institute of Standards and Science) and Kyunghee University Hospital in 2019 and 2020, the effectiveness of treatment was demonstrated through analysis on EEG (brain wave), electrocardiogram (ECG), melatonin (hormone) and Insomnia Severity Index (ISI).

The VNS technology applied to amofit S was developed based on thousands of peer-reviewed papers, and its effectiveness was proven in the actual clinical trials. In a placebo-controlled study conducted at the KRISS research institute, amofit S increased activities of the parasympathetic nervous system by up to 187%.

CONCLUSION

The result of analysis of ECG to evaluate the stress relaxation effects of AMO+ products are as follows:

1) There were significant changes in HF ratio on ECG after use of AMO+ for a short term (2 hours). It is thought that the parasympathetic nervous system is activated by wearing the product in the experiment. It is considered that AMO+ induces relaxation and sleep because parasympathetic activation dilates blood vessels and relaxes the mind and body.
2) However, there was no significant difference in HF ratio on ECG after use of fake product for a short term (2 hours).
3) There were significant changes in HF ratio on ECG after use of AMO+ in a long term (72 hours). This demonstrated that AMO+ not only has the short term effects, but also provides the long term effects, activating the parasympathetic nervous system.
4) The effect of activating the parasympathetic nervous system of AMO+ is considered effective for sympathetic hyperactivity (immune depression, increased fatigue, insomnia, etc.) suffered by many modern people due to heavy work load and stress.

In a clinical trial conducted at Kyung Hee University Hospital in 2019, the sleep improvement effect was demonstrated through analysis on Insomnia Severity Index (ISI).

We conducted a 30-day study with adults who self-reported sleep difficulties and after using AMO+, we found that: 95% of participants improved their overall Sleep Score; 85% were more satisfied with their sleep pattern; 75% reported positive impact on their daily functioning. A statistically significant reduction in mean Insomnia Severity Index (ISI) score from 15.7 (moderate insomnia) at baseline to 8.15 (sub-threshold insomnia) after 14 days of cVES treatment was observed. ISI score reduced by 7.55 (i.e., 48% reduction).

In a clinical trial conducted at the KRISS (Korea Research Institute of Standards and Science) in 2020, EEG (brain wave), electrocardiogram (ECG) and melatonin (sleep-inducing hormone) were analyzed to demonstrate the effectiveness on the activation of parasympathetic nervous system of the ANS (autonomic nervous system) and the improvement in sleep, stress, anxiety, and brain function.

Alpha brain wave power

HRV HF (level of parasympathetic nerve) ratio

Melatonin hormone level

Subjective evaluation

CONCLUSION

The HF ratio increased in both normal individuals and insomnia patients, indicating stress reduction. In the electroencephalogram (EEG) analysis, the increase of alpha wave ratios in F3, F4, Fp1, and Fp2 positions in insomnia patients after wearing real devices indicates stress reduction. In the saliva test, the increase in melatonin levels in insomnia patients at nighttime indicates an increase in sleep-inducing effects. Thus, real AMO+ devices reduce stress and improve sleep induction.

In 2012, a team of young scientists studying chemistry, biology and computer engineering at the University of Illinois discovered a treatment protocol that rapidly increases the heart rate variability (HRV) by using mild electromagnetic signals during a bioelectromagnetics experiment. In the additional clinical studies, the team identified the possibility to restore the balance of the autonomic nervous system and treat age-related chronic diseases.

In 2016, AMO Lab was established as a bioelectronics company in the United States and South Korea based on its proprietary neurostimulation platform.

Our Mission

Age-related chronic diseases cause significant economic, personal and social burdens for individuals, families and communities. 

Our mission is to delay, halt or even reverse aging, which is the ultimate goal of humanity, with natural, safe therapies without any side effect.

Non-Contact Bioelectronic Technology

AMO+, the first commercial product of AMO Lab, is a consumer wellness product that improves the quality of sleep through a unique non-invasive, non-contact approach for vagus nerve stimulation.

This innovative wearable sleep device has been completed as a result of persistent commitment and clinical studies of young scientists with their vision for the future of bioelectronics.

Since April 2022, we have been shipping the products from our warehouses in the United States, Netherlands, and South Korea to over 2,400 backers who supported this campaign.

Scientific Evidence - The VNS technology behind amofit S is backed by 4,000+ peer-reviewed papers

Our academic paper was published in the international journal 'Springer Nature' in July 2019.

CONCLUSION

LF oscillation represents vasomotor activity, which indicates activity and stress. On the other hand, the HF oscillation corresponds to respiratory activity, which represents relaxation. A significant difference was found in the case of HF power of ECG. The ECG HF component is a representation of vagal activity [14]. ECG HF power reflects the parasympathetic nervous system activity. The HF power increase indicates an improvement of parasympathetic nervous system activity. The rise of High Frequency (HF) components indicates improved vagal nerve activity, which is observed in Fig. 3 after using the VNS device. There is a significantly different HF ratio between ECG acquisition before VNS and after VNS device usage.

© Springer Nature Switzerland AG 2020 T. Ahram (Ed.): AHFE 2019, AISC 973, pp. 57–62, 2020.
https://doi.org/10.1007/978-3-030-20476-1_7

Our academic paper was published in the international journal 'Springer Nature' in July 2020.

 CONCLUSION

This study concludes that the ECG analysis of the HF ratio for the real device shows a significant increase in the HF ratio and reduction in stress. In the EEG analysis, the increase in the alpha power ratio of F3, F4, Fp1, and Fp2 indicates stress reduction. Based on the salivary melatonin results, the nighttime melatonin level of insomnia persons after using the real device shows a significant value, resulting in induced sleep in insomnia persons. The subjective evaluation also shows a satisfactory level after the use of the real device. Thus, the real AMO+ device reduces stress and improves sleep induction. It provides sleep improvement for individuals who cannot fall asleep easily due to stress, people who sleep less than 7 hours, and people suffering from sleep problems. It is also helpful for wellness purposes for individuals such as active people who care about wellness and want to improve their body functions, people who need their heart rate and respiration rate stabilized, and people who are living uncomfortably due to stress. Although this study is limited to the analysis of bio-signals and melatonin levels, the future study will focus on full night sleep monitoring for insomnia persons in order to assess overnight sleep quality.

© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2020 T. Ahram and C. Falcão (Eds.): AHFE 2020, AISC 1217, pp. 579–585, 2020.
https://doi.org/10.1007/978-3-030-51828-8_76